TCAF1 promotes TRPV2-mediated Ca2+ release in response to cytosolic DNA to protect stressed replication forks
Abstract The protection of the replication fork structure under stress conditions is essential for genome Horse Bridle Accessories maintenance and cancer prevention.A key signaling pathway for fork protection involves TRPV2-mediated Ca2+ release from the ER, which is triggered after the generation of cytosolic DNA and the activation of cGAS/STING.T